Smolina N. V. Dobretsov G. E. Syrejshchikova T. I. Gamburg Yu. D., Kalinina V. V., Gryzunov Yu. A.

European Journal of Biophysics

2013

Vol. 1, N 2

22-27

English

We are proposing a new technique for studying interaction of charged biomolecules. It is based on a difference between nitrate and chloride anion influence on electrostatic interactions in order to detect the role of positively charged guanidine groups of proteins. This comparison was demonstrated for human serum albumin (HSA) interaction with a fluorescent reporter, CAPIDAN. Nitrate anions lower their binding constant (K). There are two causes that are responsible for that K decrease induced by nitrate. FULL TEXT+

Смолина Наталья Викторовна 2013-05-31

Human Serum Albumin, Drug-Binding Site, Negatively Charged Ligands, Ngatively Charged Ligands, Fluorescent Probe CAPIDAN

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