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Grigoroiu-Serbanescu M. Herms S. Muhleisen T.W. Georgi A., Diaconu C.C., Strohmaier J., Czerski P., Hauser J., Leszczynska-Rodziewicz A., Jamra R., Babadjanova G., Tiganov A., Krasnov V.N. et al.
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American Journal of Psychiatry
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Two recent studies reported evidence for association between genetic variation of the positional candidate gene P2RX7 on chromosome 12q24 and bipolar I disorder (BPI) and one study found association with unipolar major depression (Mdd-UP). In the present work, we aimed to replicate the SNP that showed the strongest association in the above-mentioned studies, namely rs2230912 (P2RX7-E13A) resulting in a change of the amino acid glutamine to arginine at position 460 (Gln460Arg), in four European bipolar I disorder samples from Germany, Poland, Romania, and Russia totaling 1,445 patients, in a German sample of recurrent Mdd-UP patients (N = 640), and a control sample of 2,006 subjects.
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