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Perugi G. Angst J. Azorin J.M. Bowden Ch. L., Mosolov S.N., Reis J., Vieta E., Young A.H.
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Depressive mixed state, defined as the presence of 3 or more manic/hypomanic features, was present in around one-third of patients experiencing an MDE. The valid symptom, illness course and family history RBDC criteria we assessed identified 4 times more MDE patients as having mixed features and yielded statistically more robust associations with several illness characteristics of bipolar disorder than did DSM-5 criteria.
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