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Lyubov E.B. Ignatenko S.A.
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Neuroscience and Behavioral Physiology
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Depressive disorders (DD) have a high risk of recurrence and involve impairments to patients’ daily and social functioning and quality of life; these factors result in a high socioeconomic burden. Optimization of antidepressant use on the basis of the risk: benefit ratio and evidence-based resource-sparing potential is important for lightening of the load of DD, along with targeted psychosocial intervention and monitoring of compliance with the long-term therapy regime. Various aspects of the evidence-based selection of antidepressants for the treatment of DD on the basis of combined pharmacoepidemiological and pharmacoeconomic assessments of state-of-the-art agents (including SSRI and SNRI) are discussed.
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