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Perugi G., Angst J. Azorin J.‐M. Bowden C. L., Caciagli A., Mosolov S,. Vieta E., Young A.H. for the BRIDGE‐II‐Mix Study Group
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Acta Psychiatrica Scandinavica
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The study focused on the relationship between mixed depression and borderline personality disorder (BPD). The sample comprised 2811 patients with a major depressive episode (MDE). Clinical characteristics were compared in patients with (BPD+) and without (BPD−) comorbid BPD and in BPD+ with (MXS+) and without (MXS−) mixed features according to DSM‐5 criteria. A total of 187 patients (6.7%) met the criteria for BPD. A DSM‐IV‐TR diagnosis of bipolar disorder (BD) was significantly more frequent in patients with BPD+ than in patients with BPD. Patients with BPD+ were significantly younger and reported lower age at onset than BPD−. Patients with BPD+ also showed more hypomania/mania in first‐degree relatives in comparison with patients with BPD−, as well as more psychiatric comorbidity, mixed features, atypical features, suicide attempts, prior mood episodes and antidepressant‐induced hypo/manic switches.
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