Forstner A.J. Hecker J. Hofmann A. … Krasnov V.N., Chuchalin A., Abramova L.I., Tiganov A.S. et al.

PLOS One

2017

Vol. 12, N 2

doi.org/10.1371/journal.pone.0171595

English

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD.

Администратор С.А.Т. 2018-04-02

Bipolar disorder, neuropsychiatric disease, genome-wide, treatment,

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