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Mnatsakanian E.V. Kryukov V.V. Antipova O.S. Krasnov V.N.
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We aimed at studying the differences in brain activity
of patients with uni- and bipolar depression, recorded during the
anticipation of negative emotional vs neutral visual stimuli. All
patients were in the very beginning of their treatment because of
the depressive episode.
Methods: 128-Channel EEG was recorded in 12 patients (6 female)
with major depressive disorder (MDD) and 12 patients (5 female)
with bipolar disorder (BD), while they performed categorization of
images as humans or animals. Half of the photographs were neutral
and half were showing angry/aggressive people or animals. A pattern
(the cue) was presented 2 s prior to the picture; and its meaning was
not explained. We analyzed the slow wave (CNV) recorded during
the picture anticipation.
Results: Due to cue-picture association established in our
contingency-unaware patients, there were alterations in CNV during
angry vs neutral face anticipation – the emotional modulation (EM).
MDD patients showed EM in
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