Uzbekov M. Syrejshchikova T. Smolina N. Maximova N., Shikhov S., Brilliantova V.

BioMedical

2019

Vol. 21, N 4

16103-16105

English

Recent data indicate that different pathological conditions are followed not only by the disturbances in protein concentration but also by changes of their physicochemical properties which are manifested, in particular, in the conformational changes. Such changes can be detected using several biophysical methods: crystallographic measurements, nuclear magnetic spectroscopy, nonradioactive energy transfer, equilibrium dialysis, ultrafiltration, and fluorescence spectroscopy. The last method is the most informative one. Specific molecular fluorescence probes played an important role in such studies. The probes represent analogs of natural ligands and drugs and serve as markers of the binding sites of the protein molecule. The fluorescence of the probes is extremely sensitive to minor variations in the conformation and physicochemi.

Администратор КМЕА 2020-05-28

antidepressant , antidepressant therapy, albumin, anxious depression, fluorescence probe

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