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Maslenikov N.A. Tsukarzi E.E. Mosolov S.N.
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Depression is the most common cooccurring syndrome in schizophrenia, which deteriorates quality of life and outcome of disease. Insufficient clinical response to adequate pharmacotherapy determines rising interest to brain stimulation techniques such as rTMS. The aims of this study were to evaluate safety and efficacy of rTMS for treatment-resistant depression in schizophrenia and to find out possible predictors of response. Methods.– 31 schizophrenia (ICD-10) patients with prominent negative symptoms and depression (CDSS≥6) on constant combined pharmacotherapy (effective antipsychotic + ineffective antidepressant of the 2nd line) in adequate dosing regimen and exposition (≥6 weeks) were included in the study. Patients received 15-HzrTMSon the left dorsolateral prefrontal cortex (100% intensity, 15 sessions of 1800 pulses). Neuro-MS/D stimulator (“Neurosoft”, Russia) with 8-shaped coil was used.
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