Poydasheva A. Sinisyn D. Bakulin I. Suponeva N., Mosolov S., Piradov M.

Clinical Neurophysiology

2019

Vol. 130, N 7

25

English

Clinical efficacy of rTMS in recurrent depression (RD) is highly variable. It is important to search for approaches improving the efficacy, and choosing the target based on functional connectivity (FC) is promising. We aimed to compare the effects of the standard and FC-based rTMS targeting in RD patients. Methods: 30 pharmacoresistant RD patients (17 women, age median 40, quartiles 28, 44) were divided into two groups comparable in age, sex and RD severity. All patients received 20 sessions of high frequency rTMS of lDLPFC (20 Hz, 100% RMT, 3200 stimuli/session). In the standard targeting group, the stimulation points were 5 cm anterior to the individual APB muscle hotspots. In the FC-based targeting group, rTMS was targeted to the individual points in the left DLPFC with maximum negative correlation to subgenual cingulate (10 mm radius sphere at MNI coordinates).

Администратор КМЕА 2020-06-03

rTMS, recurrent depression, functional connectivity, FC,

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