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Verdolini N. Menculini G. PerugiI G. Murru A., Samalin L., Angst J., Azorin J.M., Bowden C.L., Mosolov S., Young A.H., BarbutiI M., Popovic D., Vieta E., PacchiarottiI I.
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European Neuropsychopharmacology
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Affective lability (AL) is the predisposition to rapidly reversible and marked shifts in affective episodes, extremely sensitive to environmental events with intense behavioral responses. Mood reactivity (MR) is defined as a change of mood restrictively in response to positive stimuli and represents a core criterion for atypical depression [2]. AL was found to be one of the three most frequent state features in mixed depression, together with agitation and irritability [3]. In addition, it is widely supported that patients with depressive mixed states of- ten display atypical features [4,5]. Despite this, AL was excluded from the DSM-5 “with mixed features” specifier.
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