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Anmella G. Corponi F. Pacchiarotti I. Verdolini N., Samalin L., Popovic D., Azorin J.M., Angst J., Bowden C.L., Mosolov S., Young A.H., Perugi G., Vieta E., Serretti A., Murru A.
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European Neuropsychopharmacology
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Major depression (MDE) is a clinical syndrome occuring in approximately one out of six adults over a life-time. This syndromal transdiagnostic nosographic construct bears more than 1400 combinations of symptoms which may fulfil a diagnosis of MDE, and straddles Major
Depressive Disorder (MDD) and Bipolar Disorder (BD). Despite cross-sectional similarities, these two conditions show differences in their neurobiological underpinnings, clinical
presentation, course of illness and, ultimately, functional outcome. Thus, prognostic and treatment implications warrant a differentiation between these two disorders.
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