Childhood violence experience interacts with BDNF Val158Met polymorphism and modify internet addiction risk

Chuprova N. Merkulova T. Solovieva M. Nikolishin A., Trusova A., Grechany S., Soldatkin V., Yakovlev A., Ponizovsky P., Ilyuk R.D., Egorov A., Krupitsky E., Kibitov A.

Издание:

European Psychiatry

Год издания:

2022

Номер:

Vol. 65, S1

Страницы:

S128

Язык:

English

Аннотация:

Introduction: Internet-addiction (IA) is one of the most common non-chemical (or behavioral) addictions with genetic impact and substantial effects of psychological and personality characteristics, taking into account the childhood traumatic experience. Gene-environment interactions (GxE) may substantially impact on the risk of Internet-addiction (IA). Objectives: To test the associations between the functional polymorphism rs6265 (Val66Met) in brain-derived neurotrophic factor (BDNF) gene, affecting BDNF function, and childhood traumatic experience and their GxE interactions with IA risk. Methods: In total 456 participants were screened with Chinese Internet Addiction Scale (CIAS) to cut a cohort on two groups: IA (CIAS total score ≥ 65, n=100) and controls (CIAS total score less 64, n=356). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used to assess childhood traumatic experience using its main domains: parents (P), family (F), abuse (A) and violence (

Добавил:

Понизовский Павел Александрович 2023-01-22

Ключевые слова:

BDNF Val158Met , Internet addiction, adverse childhood experiences, ,

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