Adverse childhood experience referring to parental relationship is associated with the risk of alcohol dependence and with COMT Val158Met polymorphism, but out of gene-environment interactions

Adverse childhood experience referring to parental relationship is associated with the risk of alcohol dependence and with COMT Val158Met polymorphism, but out of gene-environment interactions

Авторы:

Merkulova T. Chuprova N. Solovieva M. Nikolishin A., Kibitov A., Grechany S., Baranok N., Rybakova K., Soldatkin V., Yakovlev A., Trusova A., Ponizovsky P., Krupitsky E.

Издание:

European Psychiatry

Год издания:

2022

Номер:

Vol. 65, S1

Страницы:

S127

Язык:

English

Аннотация:

Introduction: Gene-environment interactions (GxE) are considered to make a substantial impact on the risk of alcohol dependence (AD). Objectives: To test the associations between the functional polymorphism Val158Met (rs6265) in the catechol-O-methyl transferase (COMT) gene, affecting dopamine neurotransmission, and adverse childhood experiences (ACE) and their GxE interactions with AD risk. Methods: The study included 149 AD inpatients (mean age 29.9 (SD=3.91), 16.1% females) and 201 healthy volunteers (23.3 (2.48), 30.1% females). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used for assessing ACE. COMT Val158Met polymorphism was detected by RT-PCR. Results: First, COMT Val158Met polymorphism was associated only with adverse childhood experience referring o parental relationship (ACE-IQ), but differently in two groups. Healthy minor Met158 carriers have lower scores on the subscale “relationship with parents/guardians” (P) (p=0.025) and “physical negl

Добавил:

Понизовский Павел Александрович 2023-01-22

Ключевые слова:

Alcohol dependence, GxE interaction, , ,

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