Murashko A.A. Pavlov K.A. Pavlova O.V. Gurina O.I., Shmukler A.

Neuropsychobiology

2021

Vol. 81(1)

1-18

English

Objective: The objective of this study was to provide com prehensive evidence synthesis including all available up-to date data about the prevalence of N-methyl D-aspartate receptor (NMDAR) antibodies (ABs) in psychotic patients in order to evaluate the clinical relevance of ABs as well as to specify potential explanations of the heterogeneity of the findings and determine areas for further research. Methods: A literature search was conducted using the PubMed/Medline, Web of Knowledge, and Scopus databases. Results: Forty-seven studies and 4 systematic reviews (including 2 meta-analyses) were included in the present review. Studies that used cell-based assays (CBAs) provided heterogeneous results on AB prevalence, obviously depending on the type of detection assay and sample characteristics. Improvement of AB detection methods is necessary to determine the real prevalence of ABs across different groups of patients and healthy people. Live CBAs seem to have better sensitivity but probab

Администратор С.А.Т. 2023-09-09

N-methyl-D-aspartate receptor, Antibodies, Psychosis, Schizophrenia, Autoimmune encephalitis

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